Technology Process of N-[(2R,3S)-2-(3-Benzyloxy-propyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide
There total 11 articles about N-[(2R,3S)-2-(3-Benzyloxy-propyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 82 percent / DBU; LiCl / acetonitrile / 0 °C
2: 65 percent / NaOH; tBuOCl; (DHQD)2PHAL / K2[OsO2(OH)4] / propan-1-ol; H2O / 1 h / 0 °C
3: 84 percent / DEAD; Ph3P / tetrahydrofuran
4: 95 percent / K2CO3 / methanol
5: 80 percent / HN3; DEAD; Ph3P / benzene; tetrahydrofuran
6: 100 percent / K2CO3; H2O / methanol
7: 100 percent / 0 °C
8: 2-chloro-1-methylpyridinium iodide; Et3N / acetonitrile / 20 - 55 °C
9: Ph3P / methanol; H2O
10: acetonitrile; aq. NaHCO3
With
sodium hydroxide; tert-butylhypochlorite; tris-(2-chloro-ethyl)-amine; 2-chloro-1-methyl-pyridinium iodide; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate;
K2;
In
tetrahydrofuran; methanol; propan-1-ol; water; sodium hydrogencarbonate; acetonitrile; benzene;
DOI:10.1016/S0040-4039(01)00757-2
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 88 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / -78 °C
2: 82 percent / DBU; LiCl / acetonitrile / 0 °C
3: 65 percent / NaOH; tBuOCl; (DHQD)2PHAL / K2[OsO2(OH)4] / propan-1-ol; H2O / 1 h / 0 °C
4: 84 percent / DEAD; Ph3P / tetrahydrofuran
5: 95 percent / K2CO3 / methanol
6: 80 percent / HN3; DEAD; Ph3P / benzene; tetrahydrofuran
7: 100 percent / K2CO3; H2O / methanol
8: 100 percent / 0 °C
9: 2-chloro-1-methylpyridinium iodide; Et3N / acetonitrile / 20 - 55 °C
10: Ph3P / methanol; H2O
11: acetonitrile; aq. NaHCO3
With
sodium hydroxide; oxalyl dichloride; tert-butylhypochlorite; tris-(2-chloro-ethyl)-amine; 2-chloro-1-methyl-pyridinium iodide; water; potassium carbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate;
K2;
In
tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; sodium hydrogencarbonate; acetonitrile; benzene;
DOI:10.1016/S0040-4039(01)00757-2
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 65 percent / NaOH; tBuOCl; (DHQD)2PHAL / K2[OsO2(OH)4] / propan-1-ol; H2O / 1 h / 0 °C
2: 84 percent / DEAD; Ph3P / tetrahydrofuran
3: 95 percent / K2CO3 / methanol
4: 80 percent / HN3; DEAD; Ph3P / benzene; tetrahydrofuran
5: 100 percent / K2CO3; H2O / methanol
6: 100 percent / 0 °C
7: 2-chloro-1-methylpyridinium iodide; Et3N / acetonitrile / 20 - 55 °C
8: Ph3P / methanol; H2O
9: acetonitrile; aq. NaHCO3
With
sodium hydroxide; tert-butylhypochlorite; tris-(2-chloro-ethyl)-amine; 2-chloro-1-methyl-pyridinium iodide; water; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; triphenylphosphine; diethylazodicarboxylate;
K2;
In
tetrahydrofuran; methanol; propan-1-ol; water; sodium hydrogencarbonate; acetonitrile; benzene;
DOI:10.1016/S0040-4039(01)00757-2
