(E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide

Base Information

Chemical Name:(E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide
CAS No.:1357262-99-7
Molecular Formula:C₂₅H₂₃N₅O
Molecular Weight:409.491
Hs Code.:

Synonyms:(E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide

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Chemical Property of (E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide

Chemical Property:

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Technology Process of (E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide

There total 5 articles about (E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357263-41-2
(1-{4-[3-((E)-2-carbamoyl-vinyl)-7-phenyl-imidazo[1,2-b]pyridazin-6-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

: 1357262-99-7
(E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield:

: 1357263-07-0
{1-[4-(7-phenyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1357262-99-7
(E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / chloroform / 1 h / Reflux

2: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / acetonitrile / 1 h / 110 °C / Microwave irradiation

3: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; chloroform; acetonitrile;

Reference yield:

: 1357263-05-8
6-chloro-7-phenyl-imidazo[1,2-b]pyridazine

: 1357262-99-7
(E)-3-{6-[4-(1-amino-cyclobutyl)-phenyl]-7-phenyl-imidazo[1,2-b]pyridazin-3-yl}-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 24 h / 90 °C / Microwave irradiation; Inert atmosphere

2: N-Bromosuccinimide / chloroform / 1 h / Reflux

3: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / acetonitrile / 1 h / 110 °C / Microwave irradiation

4: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; palladium diacetate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; 1,2-dimethoxyethane; chloroform; acetonitrile;