tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate

Base Information

• Chemical Name: tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate
• CAS No.: 1032528-06-5
• Molecular Formula: C21H32BNO4
• Molecular Weight: 373.3
• Hs Code.: 2934999090
• Mol file: 1032528-06-5.mol

Synonyms:tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate;[1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]cyclobutyl]carbamic acid tert-butyl ester;CarbaMic acid, N-[1-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclobutyl]-, 1,1-diMethylethyl ester

Chemical Property of tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate

Chemical Property:

• Boiling Point: 481.0±34.0 °C(Predicted)
• PKA: 11.98±0.20(Predicted)
• PSA: 56.79000
• Density: 1.08
• LogP: 4.28060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate

There total 8 articles about tert-butyl 1-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate (1032350-06-3) + bis(pinacol)diborane (73183-34-3) → {1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester (1032528-06-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In tetrahydrofuran; for 5h; Reflux;

Reference yield:

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate (1032349-96-4) + bis(pinacol)diborane (73183-34-3) → {1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester (1032528-06-5)

Guidance literature:

With potassium acetate; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 46h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → {1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester (1032528-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloromethane; water

1.2: 20 °C / Inert atmosphere

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 3 h / Reflux

With potassium acetate; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate

bis(pinacol)diborane

di-tert-butyl dicarbonate

tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

Downstream raw materials:

tert-butyl {1-[4-(2-phenyl-9-pyrazin-2-yl[1,2,4]triazolo[4',3':1,6]pyrido[2,3-b]pyrazin-3-yl)phenyl]cyclobutyl}carbamate

7-[4-(1-amino-cyclobutyl)-phenyl]-4-chloro-3-methyl-8-phenyl-3H-chromeno[7,8-d]imidazol-6-one hydrochloride

(1-{4-[6-oxo-8-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1,6-dihydro-chromeno[7,8-d]imidazol-7-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

(1-{4-[6-oxo-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6-dihydro-chromeno[7,8-d]imidazol-7-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

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