(S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester

Base Information

Chemical Name:(S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester
CAS No.:99198-14-8
Molecular Formula:C₂₉H₄₄N₂O₆
Molecular Weight:516.678
Hs Code.:

Synonyms:(S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester

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Chemical Property of (S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester

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Technology Process of (S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester

There total 14 articles about (S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 542-69-8
1-iodo-butane

: 99198-12-6
tert-butyl (S)-3-<(S)-1-carboxy-3-cyclohexylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

: 99198-14-8
(S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 107-59-5
tert-Butyl chloroacetate

: 99198-14-8
(S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / K₂CO₃, KI / dimethylformamide / Ambient temperature

2: 67 percent / H₂ / 5 percent Pd-C / methanol / Ambient temperature

3: 20 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 85 percent / 1 N NaOH / H₂O / 2 h / Ambient temperature

5: 91 percent / NaHCO₃ / dimethylformamide / Ambient temperature

With sodium hydroxide; 4 A molecular sieve; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 6048-09-5
3-cyclohexylacrylic acid ethyl ester

: 99198-14-8
(S)-2-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-cyclohexyl-butyric acid butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / H₂ / 10 percent Pd-C / ethanol / Ambient temperature

2: 1) NaOEt; 2) H₂SO₄, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

3: 20 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 85 percent / 1 N NaOH / H₂O / 2 h / Ambient temperature

5: 91 percent / NaHCO₃ / dimethylformamide / Ambient temperature

With sodium hydroxide; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; sodium hydrogencarbonate; sodium chloride; palladium on activated charcoal; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128