N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

Base Information

Chemical Name:N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide
CAS No.:1561811-51-5
Molecular Formula:C₂₅H₂₀ClN₇O
Molecular Weight:469.933
Hs Code.:

Synonyms:N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

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Chemical Property of N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

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Technology Process of N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

There total 10 articles about N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1561811-42-4
N-(5-(hydroxymethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

: 1561811-51-5
N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

Guidance literature:: With thionyl chloride; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2013.12.055

Reference yield: 98.0%

: 1561811-51-5
N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

Guidance literature:: With thionyl chloride; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 1561811-19-5
2-chloro-4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazine

: 1561811-51-5
N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3: thionyl chloride / dichloromethane / 5 h / 20 °C

With thionyl chloride; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.12.055