N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

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Chemical Name:N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide
CAS No.:1561811-09-3
Molecular Formula:C₂₉H₂₈N₈O₂
Molecular Weight:520.594
Hs Code.:

Synonyms:N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

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Chemical Property of N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

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Technology Process of N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

There total 11 articles about N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110-91-8,99108-56-2
morpholine

: 1561810-30-7
N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)benzamide

: 1561811-09-3
N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield: 70.0%

: 110-91-8,99108-56-2
morpholine

: 1561811-51-5
N-(5-(chloromethyl)-2-methylphenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

: 1561811-09-3
N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

Guidance literature:: With potassium carbonate; In acetonitrile; for 6h; Reflux;
DOI:10.1016/j.bmc.2013.12.055

Reference yield:

: 1561811-19-5
2-chloro-4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazine

: 1561811-09-3
N-(2-methyl-5-((morpholin-4-yl)methyl)phenyl)-5-((4-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / Reflux; Inert atmosphere

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3: thionyl chloride / dichloromethane / 5 h / 20 °C

4: potassium carbonate / acetonitrile / 6 h / Reflux

With thionyl chloride; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.12.055