4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide
CAS No.:1415829-47-8
Molecular Formula:C₂₅H₂₀N₄O₃S
Molecular Weight:456.525
Hs Code.:

Synonyms:4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

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Technology Process of 4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

There total 3 articles about 4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1415830-35-1
8-chloro-2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine

: 70-55-3
toluene-4-sulfonamide

: 1415829-47-8
4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Guidance literature:: With potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In tert-butyl alcohol; for 48h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2014.09.036

Reference yield:

: 26388-13-6
1-(2-phenoxyphenyl)ethan-1-one

: 1415829-47-8
4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium hydrobromide perbromide / chloroform; ethanol / 16 h / 50 °C

2: sodium hydrogencarbonate; tert-butyl alcohol / 48 h / Reflux

3: potassium carbonate; tert-butyl alcohol / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / 48 h / Reflux; Inert atmosphere

With pyridinium hydrobromide perbromide; sodium hydrogencarbonate; potassium carbonate; tert-butyl alcohol; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos; In ethanol; chloroform;

Reference yield:

: 94402-42-3
2-bromo-1-(2-phenoxyphenyl)ethan-1-one

: 1415829-47-8
4-methyl-N-[2-(2-phenoxyphenyl)imidazo[1,2-a]pyrazine-8-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; tert-butyl alcohol / 48 h / Reflux

2: potassium carbonate; tert-butyl alcohol / bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos / 48 h / Reflux; Inert atmosphere

With sodium hydrogencarbonate; potassium carbonate; tert-butyl alcohol; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl XPhos;