(3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Base Information

Chemical Name:(3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one
CAS No.:1054667-95-6
Molecular Formula:C₄₄H₄₆N₂O₉
Molecular Weight:746.857
Hs Code.:

Synonyms:(3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

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Chemical Property of (3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

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Technology Process of (3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

There total 7 articles about (3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75-16-1
methylmagnesium bromide

: 188947-80-0
C₄₂H₄₀N₄O₇

: 1054667-95-6
(3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Guidance literature:: In tetrahydrofuran; Heating;
DOI:10.1021/jm960839i

Reference yield:

: 52287-51-1
6-bromo-1,4-benzodioxane

: 1054667-95-6
(3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi, 2.) CuCN

2: 1.) triphenylphosphine, diethyl azodicarboxylate, 2.) diphenyl phosphorazidate / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 2.5 h

3: LiAlH₄ / tetrahydrofuran / 0.33 h / Ambient temperature

4: various solvent(s) / 0.25 h / Heating

5: 1.) potassium tert-butoxide / 1.) THF, RT, 2.) THF, RT

6: 95 percent / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; n-butyllithium; diphenyl phosphoryl azide; potassium tert-butylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1021/jm960839i

Reference yield:

: 1053636-60-4
(R)-1-{(4S,5S)-5-[(R)-1-Amino-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylamine

: 1054667-95-6
(3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-4,8-bis-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-2,2-dimethyl-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: various solvent(s) / 0.25 h / Heating

2: 1.) potassium tert-butoxide / 1.) THF, RT, 2.) THF, RT

3: 95 percent / tetrahydrofuran / Heating

With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1021/jm960839i