2-hydroxybutane-1,4-diyl dimethanesulfonate

Base Information

• Chemical Name: 2-hydroxybutane-1,4-diyl dimethanesulfonate
• CAS No.: 5055-10-7
• Molecular Formula: C6H14O7S2
• Molecular Weight: 262.305
• Mol file: 5055-10-7.mol

Synonyms:

Chemical Property of 2-hydroxybutane-1,4-diyl dimethanesulfonate

Chemical Property:

• Vapor Pressure: 6.15E-14mmHg at 25°C
• Boiling Point: 540.5°Cat760mmHg
• Flash Point: 280.7°C
• Density: 1.455g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxybutane-1,4-diyl dimethanesulfonate

There total 4 articles about 2-hydroxybutane-1,4-diyl dimethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(2S)-2-tert-Butoxy-1,4-bis<(methylsulfonyloxy)>butane (167971-74-6) → (2S)-2-hydroxy-1,4-bis<(methansulfonyl)oxy>butane (5055-10-7)

Guidance literature:

With trifluoroacetic acid; for 1h; Ambient temperature;

DOI:10.1021/jo962372p

Reference yield: 74.0%

2(S)-(tetrahydropyranyloxy)-1,4-bis((methylsulfonyl)oxy)butane (76282-44-5) → (2S)-2-hydroxy-1,4-bis<(methansulfonyl)oxy>butane (5055-10-7)

Guidance literature:

With methanesulfonic acid; In ethanol; at 50 ℃; for 1h;

DOI:10.1021/jo00319a034

Reference yield: 55.0%

(S)-1,2,4-butanetriol (42890-76-6,6810-31-7) + methanesulfonyl chloride (124-63-0) → (2S)-2-hydroxy-1,4-bis<(methansulfonyl)oxy>butane (5055-10-7)

Guidance literature:

With pyridine; at -10 - 20 ℃; for 4h;

upstream raw materials:

(2S,2'RS) 2-O-(Tetrahydro-2'-pyranyl)-1,2,4-butanetriol

methanesulfonyl chloride

2(S)-(tetrahydropyranyloxy)-1,4-bis((methylsulfonyl)oxy)butane

(2S)-2-tert-Butoxy-1,4-bis<(methylsulfonyloxy)>butane

Downstream raw materials:

(2R)-2-benzyloxy-1,4-bis(methanesulfonyloxy)butane

Benzoic acid (S)-3-methanesulfonyloxy-1-methanesulfonyloxymethyl-propyl ester

Refernces

• 1、 -. "HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF". Paragraph 00175; 00176. . Retrieved 2015/12/30.
• 2、 -. "HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF". Paragraph 00138. . Retrieved 2014/10/15.