5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

Base Information

Chemical Name:5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine
CAS No.:161045-42-7
Molecular Formula:C₂₄H₃₃N₃O₅Si
Molecular Weight:471.629
Hs Code.:

Synonyms:5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

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Technology Process of 5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

There total 5 articles about 5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 161045-32-5
5'-O-t-butyldimethylsilyl-3'-C-allyl-4-N-benzoyl-2',3'-dideoxycytidine

: 161045-42-7
5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In diethyl ether; for 3h; Ambient temperature;
DOI:10.1080/15257779408010666

Reference yield:

: 120232-07-7
5'-O-(tert-butyldimethylsilyl)-3'-C-allyl-2',3'-dideoxyuridine

: 161045-42-7
5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N, DMAP / 1,2-dichloro-ethane

2: 71 percent / NaN₃ / dimethylformamide / Ambient temperature

3: 96 percent / SnCl₂, thiophenol / acetonitrile / 24 h

4: 98 percent / pyridine / 2 h

5: 35 percent / OsO₄, aq. NaIO₄ / diethyl ether / 3 h / Ambient temperature

With dmap; sodium periodate; osmium(VIII) oxide; sodium azide; thiophenol; triethylamine; tin(ll) chloride; In pyridine; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/15257779408010666

Reference yield:

: 161045-41-6
5'-O-t-butyldimethylsilyl-3'-C-allyl-2',3'-dideoxycytidine

: 161045-42-7
5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine / 2 h

2: 35 percent / OsO₄, aq. NaIO₄ / diethyl ether / 3 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; In pyridine; diethyl ether;
DOI:10.1080/15257779408010666