5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine

Base Information

Chemical Name:5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine
CAS No.:161045-43-8
Molecular Formula:C₂₄H₃₃N₃O₆Si
Molecular Weight:487.628
Hs Code.:

Synonyms:5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine

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Technology Process of 5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine

There total 6 articles about 5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 161045-42-7
5'-O-t-butyldimethylsilyl-3'-(2''-oxoethyl)-4-N-benzoyl-2',3'-dideoxycytidine

: 161045-43-8
5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-Methyl-1-butene; In tert-butyl alcohol; Ambient temperature;
DOI:10.1080/15257779408010666

Reference yield:

: 120232-07-7
5'-O-(tert-butyldimethylsilyl)-3'-C-allyl-2',3'-dideoxyuridine

: 161045-43-8
5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N, DMAP / 1,2-dichloro-ethane

2: 71 percent / NaN₃ / dimethylformamide / Ambient temperature

3: 96 percent / SnCl₂, thiophenol / acetonitrile / 24 h

4: 98 percent / pyridine / 2 h

5: 35 percent / OsO₄, aq. NaIO₄ / diethyl ether / 3 h / Ambient temperature

6: 75 percent / 2-methylbutene, NaClO₂, aq. NaH₂PO₄ / 2-methyl-propan-2-ol / Ambient temperature

With dmap; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; sodium azide; 2-Methyl-1-butene; thiophenol; triethylamine; tin(ll) chloride; In pyridine; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1080/15257779408010666

Reference yield:

: 161045-41-6
5'-O-t-butyldimethylsilyl-3'-C-allyl-2',3'-dideoxycytidine

: 161045-43-8
5'-O-t-butyldimethylsilyl-3'-carboxymethyl-4-N-benzoyl-2',3'-dideoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / pyridine / 2 h

2: 35 percent / OsO₄, aq. NaIO₄ / diethyl ether / 3 h / Ambient temperature

3: 75 percent / 2-methylbutene, NaClO₂, aq. NaH₂PO₄ / 2-methyl-propan-2-ol / Ambient temperature

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-Methyl-1-butene; In pyridine; diethyl ether; tert-butyl alcohol;
DOI:10.1080/15257779408010666