4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester

Base Information

• Chemical Name: 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester
• CAS No.: 958237-61-1
• Molecular Formula: C₁₅H₁₈F₂O₃
• Molecular Weight: 284.303
• Mol file: 958237-61-1.mol

Synonyms:4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester

Chemical Property of 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester

There total 3 articles about 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

potassium ethyl methylmalonate (103362-70-5) + 2-(2,6-difluoro-phenyl)-1-imidazol-1-yl-butan-1-one → 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester (958237-61-1)

Guidance literature:

potassium ethyl methylmalonate; With triethylamine; magnesium chloride; In acetonitrile; at 20 ℃;

2-(2,6-difluoro-phenyl)-1-imidazol-1-yl-butan-1-one; In acetonitrile; Heating;

With hydrogenchloride; In acetonitrile; at 20 ℃; Further stages.;

DOI:10.1021/jm070811e

Reference yield:

2,6-difluorophenylacetic acid (85068-28-6) → 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester (958237-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / -10 °C

2: acetonitrile

3: triethylamine; magnesium chloride / acetonitrile

With n-butyllithium; triethylamine; magnesium chloride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm200734j

Reference yield:

2-(2,6-difluorophenyl)butanoic acid (359828-70-9) → 4-(2,6-dichlorophenyl)-2-methyl-3-oxo-hexanoic acid ethyl ester (958237-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile

2: triethylamine; magnesium chloride / acetonitrile

With triethylamine; magnesium chloride; In acetonitrile;

DOI:10.1021/jm200734j

upstream raw materials:

potassium ethyl methylmalonate

2,6-difluorophenylacetic acid

2-(2,6-difluorophenyl)butanoic acid

Downstream raw materials:

6-(1-(2,6-difluorophenyl)propyl)-5-methyl-2-(methylthio)pyrimidin-4(3H)-one

6-(1-(2,6-difluorophenyl)propyl)-2-(isopropylthio)-5-methylpyrimidin-4(3H)-one

2-(sec-butylthio)-6-(1-(2,6-difluorophenyl)propyl)-5-methylpyrimidin-4(3H)-one

2-(cyclopentylthio)-6-(1-(2,6-difluorophenyl)propyl)-5-methylpyrimidin-4(3H)-one