359828-70-9Relevant academic research and scientific papers
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3 H)-ones: Effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes
Rotili, Dante,Tarantino, Domenico,Nawrozkij, Maxim B.,Babushkin, Alexandre S.,Botta, Giorgia,Marrocco, Biagina,Cirilli, Roberto,Menta, Sergio,Badia, Roger,Crespan, Emmanuele,Ballante, Flavio,Ragno, Rino,Esté, José A.,Maga, Giovanni,Mai, Antonello
, p. 5212 - 5225 (2014)
A comparison of the effects of the 6-(2-chloro-6-fluorobenzyl)-2- (alkylthio)pyrimidin-4(3H)-ones (2-Cl-6-F-S-DABOs) 7-12 and the related 6-(2,6-difluorobenzyl) counterparts 13-15 in HIV-1 infected cells and in the HIV-1 reverse transcriptase (RT) assays
Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors
Sbardella, Gianluca,Mai, Antonello,Bartolini, Sara,Castellano, Sabrina,Cirilli, Roberto,Rotili, Dante,Milite, Ciro,Santoriello, Marisabella,Orlando, Serena,Sciamanna, Ilaria,Serafino, Annalucia,Lavia, Patrizia,Spadafora, Corrado
scheme or table, p. 5927 - 5936 (2011/10/09)
A series of 5-alkyl-2-(alkylthio)-6-(1-(2,6-difluorophenyl)propyl)-3,4- dihydropyrimidin-4(3H)-one derivatives (3a-h) belonging to the F 2-DABOs class of non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) are endowed with a strong a
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4 (3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Mai,Sbardella,Artico,Ragno,Massa,Novellino,Greco,Lavecchia,Musiu,La Colla,Murgioni,La Colla,Loddo
, p. 2544 - 2554 (2007/10/03)
5-Alkyl-2-(alkylthio)-6-(2,6-difluorobenzyl)-3,4-dihydropyrimidin-4(3H)-ones (S-DABOs 2) have been recently described as a new class of human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) active at nan
