2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide

Base Information

Chemical Name:2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide
CAS No.:919435-02-2
Molecular Formula:C₁₈H₁₆N₄O₄S
Molecular Weight:384.415
Hs Code.:

Synonyms:2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide

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Chemical Property of 2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide

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Technology Process of 2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide

There total 4 articles about 2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 64297-92-3
N-(β-phenethyl)-2-bromoacetamide

: 23766-30-5,203268-74-0
5-(p-nitrophenyl)-2-mercapto-1,3,4-oxadiazole

: 919435-02-2
2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.14233/ajchem.2013.14333

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 919435-02-2
2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 1 h / Reflux

2: hydrazine / methanol / 3 h / 20 °C

3: carbon disulfide; potassium hydroxide / ethanol / 5 h / Reflux

4: sodium hydride / N,N-dimethyl-formamide / 20 °C

With carbon disulfide; sulfuric acid; sodium hydride; potassium hydroxide; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.14233/ajchem.2013.14333

Reference yield:

: 99-77-4
ethyl 4-nitrobenzoate

: 919435-02-2
2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-phenylethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / methanol / 3 h / 20 °C

2: carbon disulfide; potassium hydroxide / ethanol / 5 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide / 20 °C

With carbon disulfide; sodium hydride; potassium hydroxide; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.14233/ajchem.2013.14333