1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Base Information

Chemical Name:1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine
CAS No.:859210-59-6
Molecular Formula:C₃₀H₄₄N₄O₉SSi
Molecular Weight:664.852
Hs Code.:

Synonyms:1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Suppliers and Price of 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

There total 5 articles about 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 859210-57-4
1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)thymine

: 859210-59-6
1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 8.5h;
DOI:10.1021/jm050091g

Reference yield:

: 3-amino-5-O-benzyl-3-C-cyano-3-deoxy-3-N-mesyl-1,2-O-sulfinyl-α-D-ribofuranose

: 859210-59-6
1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium sulfate; hexamethyldisilazane / Heating

1.2: 2 h / 125 °C

1.3: 82 percent / TBAF*3H₂O / tetrahydrofuran / 0.5 h

2.1: 89 percent / imidazole / dimethylformamide / 20 °C

3.1: 88 percent / pyridine / CH₂Cl₂ / 8.5 h / 20 °C

With pyridine; 1H-imidazole; ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050091g

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 859210-59-6
1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-mesyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / imidazole / dimethylformamide / 20 °C

2: 88 percent / pyridine / CH₂Cl₂ / 8.5 h / 20 °C

With pyridine; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050091g