C₆₂H₈₉N₇O₁₅

Base Information

• Chemical Name: C₆₂H₈₉N₇O₁₅
• CAS No.: 161708-52-7
• Molecular Formula: C₆₂H₈₉N₇O₁₅
• Molecular Weight: 1172.43
• Mol file: 161708-52-7.mol

Synonyms:C₆₂H₈₉N₇O₁₅

Chemical Property of C₆₂H₈₉N₇O₁₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₂H₈₉N₇O₁₅

There total 15 articles about C₆₂H₈₉N₇O₁₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl> hydrochloride (130008-93-4) + N-Cbz-3,4-didehydro-L-prolyl-N-methyl-D-leucine (161708-41-4) → C62H89N7O15 (161708-52-7)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; 1.) 0 deg C, 30 min, 2.) r.t., 2 h;

DOI:10.1021/jo00097a022

Reference yield:

Z-D-Leu-OH (28862-79-5) → C62H89N7O15 (161708-52-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / KOH, Bu₄N(+)HSO₄(-) / tetrahydrofuran

2: 78 percent / Et₃N, DCC, DMAP / CH₂Cl₂ / 22 h / Ambient temperature

3: 98 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate / 5 h / 2068.6 Torr

4: 1.) BOP-Cl, NMM, 2.) NMM / 1.) CH₂Cl₂, -15 deg C, 30 min, 2.) 0 deg C, 6 h

5: 75 percent / TBAF / tetrahydrofuran / 1 h / 0 °C

6: 92 percent / BOP, NMM / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) r.t., 2 h

With 4-methyl-morpholine; dmap; potassium hydroxide; tetrabutyl ammonium fluoride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

DOI:10.1021/jo00097a022

Reference yield:

N-methyl-N-(benzyloxycarbonyl)-D-leucine (65635-85-0) → C62H89N7O15 (161708-52-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / Et₃N, DCC, DMAP / CH₂Cl₂ / 22 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate / 5 h / 2068.6 Torr

3: 1.) BOP-Cl, NMM, 2.) NMM / 1.) CH₂Cl₂, -15 deg C, 30 min, 2.) 0 deg C, 6 h

4: 75 percent / TBAF / tetrahydrofuran / 1 h / 0 °C

5: 92 percent / BOP, NMM / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) r.t., 2 h

With 4-methyl-morpholine; dmap; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

DOI:10.1021/jo00097a022

upstream raw materials:

cyclo--5-methylheptanoyl>oxy-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl> hydrochloride

N-Cbz-3,4-didehydro-L-prolyl-N-methyl-D-leucine

Z-D-Leu-OH

N-methyl-N-(benzyloxycarbonyl)-D-leucine

Downstream raw materials:

Cyclo<(N-L-prolyl-N-methyl-D-leucyl)-O-<oxy>-3-oxo-2,5-dimethylhexanoyl>-L-leucyl>-L-prolyl-N,O-dimethyl-L-tyrosyl>-L-threonyl>