Cbz-N-Methyl-D-leucine

Base Information

• Chemical Name: Cbz-N-Methyl-D-leucine
• CAS No.: 65635-85-0
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Mol file: 65635-85-0.mol

Synonyms:Cbz-N-Methyl-D-leucine;Cbz-N-Me-D-Leu-OH;(R)-2-(((Benzyloxy)carbonyl)(methyl)amino)-4-methylpentanoic acid

Chemical Property of Cbz-N-Methyl-D-leucine

Chemical Property:

• PSA: 66.84000
• LogP: 2.75430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.0% ^*data from raw suppliers

(R)-2-(((Benzyloxy)carbonyl)(methyl)amino)-4-methylpentanoicacid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cbz-N-Methyl-D-leucine

There total 4 articles about Cbz-N-Methyl-D-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Z-D-Leu-OH (28862-79-5) + dimethyl sulfate (77-78-1) → N-methyl-N-(benzyloxycarbonyl)-D-leucine (65635-85-0)

Guidance literature:

With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran;

DOI:10.1021/jo00097a022

Reference yield: 90.0%

Z-D-Leu-OH (28862-79-5) + methyl iodide (74-88-4) → N-methyl-N-(benzyloxycarbonyl)-D-leucine (65635-85-0)

Guidance literature:

With sodium hydride; In acetonitrile; at 0 ℃; Inert atmosphere;

DOI:10.1039/c0ob00617c

Reference yield:

(R)-leucine (328-38-1,21675-61-6,25248-98-0,70-45-1) → N-methyl-N-(benzyloxycarbonyl)-D-leucine (65635-85-0)

Guidance literature:

DOI:10.1021/ja00256a046

upstream raw materials:

(R)-leucine

Z-D-Leu-OH

dimethyl sulfate

methyl iodide

Downstream raw materials:

N-<(benzyloxy)carbonyl>-N-methyl-D-leucine 2-(trimethylsilyl)ethyl ester

-threonine methyl ester

N-methyl[(R)-3-methyl-1-((S)-thiazol-2-yl-pyrrolidine-1-carbonyl)butyl]carbamic acid benzyl ester

Z-didemnin C