[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt

Base Information

• Chemical Name: [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt
• CAS No.: 1369389-54-7
• Molecular Formula: C₂F₃O₂*C₃₃H₄₂Cl₂N₅O₆S
• Molecular Weight: 820.714
• Mol file: 1369389-54-7.mol

Synonyms:[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt

Chemical Property of [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt

There total 3 articles about [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide (884049-25-6) + betaine (105371-61-7) + trifluoroacetic acid (76-05-1) → [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt (1369389-54-7)

Guidance literature:

betaine; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In acetonitrile;

DOI:10.1016/j.bmc.2012.01.036

Reference yield:

tert-butyl 4-(4-[2,4-dichloro-3-(2,4-dimethylquinolin-8-yloxymethyl)benzenesulfonylamino]tetrahydropyran-4-ylcarbonyl)piperazine-1-carboxylate (883969-09-3) → [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt (1369389-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.01.036

Reference yield:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid (883969-08-2) → [2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt (1369389-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

2.1: hydrogenchloride / 1,4-dioxane

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.01.036

upstream raw materials:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid

2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide

betaine

trifluoroacetic acid