2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide

Base Information

• Chemical Name: 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide
• CAS No.: 884049-25-6
• Molecular Formula: C₂₈H₃₂Cl₂N₄O₅S
• Molecular Weight: 607.558
• Mol file: 884049-25-6.mol

Synonyms:2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide

Chemical Property of 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide

There total 3 articles about 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(4-[2,4-dichloro-3-(2,4-dimethylquinolin-8-yloxymethyl)benzenesulfonylamino]tetrahydropyran-4-ylcarbonyl)piperazine-1-carboxylate (883969-09-3) → 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide (884049-25-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

DOI:10.1021/jm061143k

Reference yield:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid (883969-08-2) → 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide (884049-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 7-aza-1-hydroxybenzotriazole / CH₂Cl₂ / 0.5 h / 0 °C

1.2: CH₂Cl₂ / 0 - 20 °C

2.1: HCl / dioxane; CH₂Cl₂ / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm061143k

Reference yield:

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester (883969-07-1) → 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[4-(piperazine-1-carbonyl)-tetrahydro-pyran-4-yl]-benzenesufonamide (884049-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. NaOH / acetonitrile / 4 h / Heating

2.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 7-aza-1-hydroxybenzotriazole / CH₂Cl₂ / 0.5 h / 0 °C

2.2: CH₂Cl₂ / 0 - 20 °C

3.1: HCl / dioxane; CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1021/jm061143k

upstream raw materials:

tert-butyl 4-(4-[2,4-dichloro-3-(2,4-dimethylquinolin-8-yloxymethyl)benzenesulfonylamino]tetrahydropyran-4-ylcarbonyl)piperazine-1-carboxylate

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester

4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid

Downstream raw materials:

[7-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-7-oxo-heptyl]trimethylammonium trifluoroacetate salt

[6-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-6-oxo-hexyl]-trimethyl-ammonium trifluoroacetate salt

[4-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydropyran-4-carbonyl)-piperazin-1-yl)-4-oxo-butyl]-trimethyl-ammonium trifluoroacetate salt

[2-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-2-oxo-ethyl]-trimethylammonium trifluoroacetate salt