(2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

Base Information

Chemical Name:(2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate
CAS No.:787635-87-4
Molecular Formula:C₂₁H₃₁NO₂
Molecular Weight:329.483
Hs Code.:

Synonyms:(2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

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Chemical Property of (2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

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Technology Process of (2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

There total 1 articles about (2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97-94-9
triethyl borane

: 600734-37-0
(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl 2H-azirine-3-carboxylate

: (2S)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

: 787635-87-4
(2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

Guidance literature:: With oxygen; copper(l) chloride; In hexane; dichloromethane; at -105 ℃; for 0.0833333h; Further Variations:; Reagents; Solvents; Product distribution;
DOI:10.1039/b408532a

Reference yield: 80.0%

: 787635-87-4
(2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

: 100-39-0
benzyl bromide

: 865163-74-2
(R)-1-Benzyl-2-ethyl-aziridine-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 5h; Heating;
DOI:10.1016/j.tet.2005.06.076

Reference yield:

: 787635-87-4
(2R)-(1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-ethylaziridine-2-carboxylate

: ((R)-1-Benzyl-2-ethyl-aziridin-2-yl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / potassium carbonate / acetonitrile / 5 h / Heating

2: LiAlH₄ / diethyl ether; tetrahydrofuran / 1.5 h / -78 - 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1016/j.tet.2005.06.076