N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine

Base Information

Chemical Name:N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine
CAS No.:162610-65-3
Molecular Formula:C₂₂H₂₉N₃O₅
Molecular Weight:415.489
Hs Code.:

Synonyms:N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine

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Chemical Property of N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine

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Technology Process of N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine

There total 7 articles about N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 162610-63-1
N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine methyl ester

: 162610-65-3
N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃;
DOI:10.1021/jo00111a015

Reference yield:

: 622-33-3
N-benzyloxyamine

: 162610-65-3
N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Et₃N, isobutyl chloroformate / 1.) THF, -17 deg C, 15 min, 2.) THF, r.t., overnight

2: 4 N HCl / dioxane / 0 °C

3: 43 percent / aq. NaOH / methanol / 2 h / Ambient temperature

4: 89 percent / 1 N NaOH / methanol / 6.5 h / Ambient temperature

5: 60 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N-methylmorpholine, HOBt / dimethylformamide / Ambient temperature

6: 90 percent / 1 N NaOH / methanol / 0 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00111a015

Reference yield:

: 45214-91-3
(2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid

: 162610-65-3
N-<3-<1-(Benzyloxy)-5,6-dimethyl-2-oxo-1,2-dihydropyraz-3-yl>propanoyl>-L-leucine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Et₃N, isobutyl chloroformate / 1.) THF, -17 deg C, 15 min, 2.) THF, r.t., overnight

2: 4 N HCl / dioxane / 0 °C

3: 43 percent / aq. NaOH / methanol / 2 h / Ambient temperature

4: 89 percent / 1 N NaOH / methanol / 6.5 h / Ambient temperature

5: 60 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N-methylmorpholine, HOBt / dimethylformamide / Ambient temperature

6: 90 percent / 1 N NaOH / methanol / 0 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00111a015