5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

Base Information

Chemical Name:5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine
CAS No.:1407519-32-7
Molecular Formula:C₂₂H₂₂ClFN₅O₃P
Molecular Weight:489.874
Hs Code.:

Synonyms:5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

Suppliers and Price of 5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

There total 5 articles about 5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1407519-32-7
5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

Guidance literature:

Reference yield:

: 1407520-37-9
5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1407519-32-7
5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Cooling with ice;

Reference yield:

: 1197953-47-1
(2-aminophenyl)dimethyl phosphorus oxide

: 1407519-32-7
5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-acrylamidobenzene)pyrimidinediamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; water / 6 h / Reflux

3.1: hydrogen; palladium on activated charcoal / methanol / 5 h / 35 °C

4.1: triethylamine / dichloromethane / 3 h / Cooling with ice

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium hydride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;