5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

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Chemical Name:5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine
CAS No.:1407520-37-9
Molecular Formula:C₁₉H₂₀ClFN₅O₂P
Molecular Weight:435.825
Hs Code.:

Synonyms:5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

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Chemical Property of 5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

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Technology Process of 5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

There total 4 articles about 5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1407520-36-8
C₂₁H₂₂ClFN₅O₃P

: 1407520-37-9
5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

Guidance literature:: With hydrogenchloride; In water; for 0.5h; Reflux;

Reference yield:

: 1407520-42-6
(2-((5-chloro-2-((4-fluoro-2-methoxy-5-nitrophenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

: 1407520-37-9
5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 35 ℃; for 5h;

Reference yield:

: 1197953-47-1
(2-aminophenyl)dimethyl phosphorus oxide

: 1407520-37-9
5-chloro-4-N-(2-dimethylphosphorylbenzene)-2-N-(2-methoxy-4-fluoro-5-aniline)pyrimidinediamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; water / 6 h / Reflux

3.1: hydrogen; palladium on activated charcoal / methanol / 5 h / 35 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium hydride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;