ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate

Base Information

Chemical Name:ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate
CAS No.:1421348-89-1
Molecular Formula:C₂₈H₃₃N₃O₃
Molecular Weight:459.588
Hs Code.:

Synonyms:ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate

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Chemical Property of ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate

Chemical Property:

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Technology Process of ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate

There total 6 articles about ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1421348-88-0
4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzoic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1421348-89-1
ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 18h;

Reference yield:

: 34970-18-8
3,3-dimethylcyclobutanecarboxylic acid

: 1421348-89-1
ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / dichloromethane / 4 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 2.25 h / -30 °C

2.2: 0.42 h / -30 - -20 °C

2.3: 4.08 h / -40 - 0 °C

3.1: toluene-4-sulfonic acid / 24 h / Reflux; Dean-Stark

4.1: sodium tetrahydroborate / methanol / 5 h / 0 °C

5.1: sodium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 18 h

With sodium tetrahydroborate; TurboGrignard; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1421348-87-9
C₂₅H₂₆N₂O₂

: 1421348-89-1
ethyl 3-(4-((3,3-dimethylcyclobutyl)(quinolin-3-ylamino)methyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 5 h / 0 °C

2: sodium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 18 h

With sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;