5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione

Base Information

• Chemical Name: 5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione
• CAS No.: 1287305-29-6
• Molecular Formula: C₂₅H₂₀N₆O₂S₅
• Molecular Weight: 596.803

Synonyms:5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione

Chemical Property of 5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione

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Technology Process of 5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione

There total 3 articles about 5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

carbon disulfide (75-15-0,12122-00-8) + 4,6-dihydroxy-2-mercaptopyrimidine (504-17-6,157796-99-1,924832-30-4) + 5-(p-tolyl)-2-(chloromethyl)-1,3,4-thiadiazole (95016-23-2) → 5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione (1287305-29-6)

Guidance literature:

carbon disulfide; 4,6-dihydroxy-2-mercaptopyrimidine; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;

5-(p-tolyl)-2-(chloromethyl)-1,3,4-thiadiazole; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1002/ardp.201000085

Reference yield:

p-toluic hydrazide (3619-22-5) → 5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione (1287305-29-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate

2.1: thiourea / tetrahydrofuran

3.1: triethylamine / dimethyl sulfoxide / 1 h / 20 °C

3.2: 4 h / 20 °C

With triethylamine; thiourea; trichlorophosphate; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/ardp.201000085

Reference yield:

2‐(chloromethyl)‐5‐(4‐methylphenyl)‐1,3,4‐oxadiazole (287197-95-9) → 5-(bis((5-p-tolyl-1,3,4-thiadiazol-2-yl)methylthio)methylene)-dihydro-2-thioxopyrimidine-4,6-(1H,5H)-dione (1287305-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thiourea / tetrahydrofuran

2.1: triethylamine / dimethyl sulfoxide / 1 h / 20 °C

2.2: 4 h / 20 °C

With triethylamine; thiourea; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/ardp.201000085

upstream raw materials:

carbon disulfide

4,6-dihydroxy-2-mercaptopyrimidine

5-(p-tolyl)-2-(chloromethyl)-1,3,4-thiadiazole

p-toluic hydrazide

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