1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride

Base Information

Chemical Name:1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride
CAS No.:1345017-10-8
Molecular Formula:C₁₈H₁₅F₃N₂O₂*ClH
Molecular Weight:384.785
Hs Code.:

Synonyms:1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride

Chemical Property:

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Technology Process of 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride

There total 5 articles about 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345017-04-0
1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

: 1345017-10-8
1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 0.0833333h;
DOI:10.1016/j.bmcl.2011.09.005

Reference yield:

: 1356537-07-9
C₁₆H₁₆FNO₄S

: 1345017-10-8
1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / 2 h / -5 °C

2: potassium carbonate / ethanol / 5 h / Reflux

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.08 h

With hydrogenchloride; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; 2: van Leusen reaction;
DOI:10.1016/j.bmcl.2011.09.005

Reference yield:

: 351-54-2
3-fluoro-p-anisaldehyde

: 1345017-10-8
1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: camphor-10-sulfonic acid / 16 h / 65 °C

2: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / 2 h / -5 °C

3: potassium carbonate / ethanol / 5 h / Reflux

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.08 h

With hydrogenchloride; camphor-10-sulfonic acid; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; 3: van Leusen reaction;
DOI:10.1016/j.bmcl.2011.09.005