1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

Base Information

Chemical Name:1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole
CAS No.:1345017-04-0
Molecular Formula:C₁₈H₁₅F₃N₂O₂
Molecular Weight:348.325
Hs Code.:

Synonyms:1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

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Chemical Property of 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

Chemical Property:

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Technology Process of 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

There total 4 articles about 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₉H₉F₂NO

: 1336938-63-6
(3-fluoro-4-methoxyphenyl)(p-toluenesulfonyl)methylisocyanide

: 1345017-04-0
1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

Guidance literature:: With potassium carbonate; In ethanol; for 5h; Reflux;
DOI:10.1016/j.bmcl.2011.09.005

Reference yield:

: 1356537-07-9
C₁₆H₁₆FNO₄S

: 1345017-04-0
1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / 2 h / -5 °C

2: potassium carbonate / ethanol / 5 h / Reflux

With potassium carbonate; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; 2: van Leusen reaction;
DOI:10.1016/j.bmcl.2011.09.005

Reference yield:

: 351-54-2
3-fluoro-p-anisaldehyde

: 1345017-04-0
1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(3,5-difluoro-4-methoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: camphor-10-sulfonic acid / 16 h / 65 °C

2: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / 2 h / -5 °C

3: potassium carbonate / ethanol / 5 h / Reflux

With camphor-10-sulfonic acid; potassium carbonate; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; 3: van Leusen reaction;
DOI:10.1016/j.bmcl.2011.09.005