[3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde

Base Information

• Chemical Name: [3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde
• CAS No.: 380847-84-7
• Molecular Formula: C₂₀H₃₆O₃Si₂
• Molecular Weight: 380.675
• Mol file: 380847-84-7.mol

Synonyms:[3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde

Chemical Property of [3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde

There total 2 articles about [3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-[3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]ethanol (949112-07-6) → [3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde (380847-84-7)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo071035l

Reference yield:

methyl 1,3-bis(tert-butyldimethylsilyloxy)phenylacetate (135388-00-0) → [3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde (380847-84-7)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 - -65 ℃; for 2.5h;

DOI:10.1271/bbb.65.2110

Reference yield: 46.0%

1-Bromoheptane (629-04-9) + [3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde (380847-84-7) → 1,3-bis(tert-butyldimethylsilyloxy)-5-[(Z)-2'-nonenyl]benzene (252913-16-9) + 1,3-bis(tert-butyldimethylsilyloxy)-5-[(E)-2'-nonenyl]benzene

Guidance literature:

1-Bromoheptane; With triphenylphosphine; In toluene;

With sodium hexamethyldisilazane; In tetrahydrofuran; hexane; toluene; at -20 ℃; for 1h;

[3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetaldehyde; In tetrahydrofuran; hexane; toluene; at -78 - 20 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1271/bbb.65.2110

upstream raw materials:

methyl 1,3-bis(tert-butyldimethylsilyloxy)phenylacetate

2-[3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]ethanol

Downstream raw materials:

1,3-bis(tert-butyldimethylsilyloxy)-5-[(Z)-2'-nonenyl]benzene

5-[3,5-bis(tert-butyl-dimethylsilanyloxy)phenyl]pentane-1,4-diol

1-[3,5-bis(tert-butyl-dimethyl-silanyloxy)-phenyl]-pent-4-en-2-ol

1,3-dihydroxy-5-[(Z)-non-2'-enyl]benzene