Boc-prolyl-4-iodoanilide

Base Information

• Chemical Name: Boc-prolyl-4-iodoanilide
• CAS No.: 329743-61-5
• Molecular Formula: C₁₆H₂₁IN₂O₃
• Molecular Weight: 416.259
• Mol file: 329743-61-5.mol

Synonyms:Boc-prolyl-4-iodoanilide

Chemical Property of Boc-prolyl-4-iodoanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-prolyl-4-iodoanilide

There total 1 articles about Boc-prolyl-4-iodoanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + p-aminoiodobenzene (540-37-4) → Boc-prolyl-4-iodoanilide (329743-61-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1021/ml4003919

Reference yield:

Boc-prolyl-4-iodoanilide (329743-61-5) → C40H50IN4O7P

Guidance literature:

Multi-step reaction with 5 steps

1: copper diacetate; triethylamine / dichloromethane / 24 h

2: trifluoroacetic acid / dichloromethane / 1 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h

With copper diacetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/acs.jmedchem.5b01321

Reference yield:

Boc-prolyl-4-iodoanilide (329743-61-5) → C32H35IN3O7P

Guidance literature:

Multi-step reaction with 5 steps

1: copper diacetate; triethylamine / dichloromethane / 24 h

2: trifluoroacetic acid / dichloromethane / 1 h

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h

5: 1-methyl-pyrrolidin-2-one; 4-methyl-morpholine; dmap / 3 h / 20 °C

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; dmap; copper diacetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/acs.jmedchem.5b01321

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

p-aminoiodobenzene