3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Base Information

Chemical Name:3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde
CAS No.:1132942-20-1
Molecular Formula:C₁₆H₁₇FN₂O₄
Molecular Weight:320.32
Hs Code.:

Synonyms:3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

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Chemical Property of 3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

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Technology Process of 3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

There total 10 articles about 3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1132942-20-1
3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Guidance literature:

Reference yield:

: C₁₆H₁₆ClFN₂O₄

: 1132942-20-1
3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at -78 ℃; for 0.583333h;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 1132942-16-5
methyl 3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzoate

: 1132942-20-1
3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; ethanol / 3 h / 20 °C

2: thionyl chloride / 0.67 h / 80 °C

3: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.58 h / -78 °C

With thionyl chloride; lithium tri-t-butoxyaluminum hydride; sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1021/acs.jmedchem.7b01630