(E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Name:(E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione
CAS No.:1132942-22-3
Molecular Formula:C₂₃H₂₂FN₃O₅
Molecular Weight:439.443
Hs Code.:

Synonyms:(E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Property of (E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

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Technology Process of (E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

There total 8 articles about (E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1132942-20-1
3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

: 2609-49-6
diethyl p-nitrobenzylphosphonate

: 1132942-22-3
(E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With potassium tert-butylate; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 1132942-16-5
methyl 3-(tert-butyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzoate

: 1132942-22-3
(E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; ethanol / 3 h / 20 °C

2: thionyl chloride / 0.67 h / 80 °C

3: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.58 h / -78 °C

4: potassium tert-butylate / dichloromethane / 1.5 h / 20 °C

With thionyl chloride; potassium tert-butylate; lithium tri-t-butoxyaluminum hydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 15018-03-8
methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

: 1132942-22-3
(E)-1-(3-(tert-butyl)-5-(3-fluoro-4-nitrostyryl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: nitric acid; acetic acid / 2.5 h / 20 °C

2.1: potassium carbonate / acetone / Reflux

3.1: iron; ammonium chloride / methanol; water / 1 h / Reflux

4.1: N,N-dimethyl acetamide; benzene / 4 h / -25 - 20 °C

4.2: 3 h / 100 °C

5.1: Selectfluor / methanol; acetonitrile / 5 h / 90 °C / Inert atmosphere

6.1: triethylamine / methanol / 18 h / 20 °C

7.1: sodium hydroxide / water; ethanol / 3 h / 20 °C

8.1: thionyl chloride / 0.67 h / 80 °C

9.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.58 h / -78 °C

10.1: potassium tert-butylate / dichloromethane / 1.5 h / 20 °C

With thionyl chloride; potassium tert-butylate; nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; Selectfluor; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetone; acetonitrile; benzene;
DOI:10.1021/acs.jmedchem.7b01630