5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine

Base Information

Chemical Name:5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine
CAS No.:1403963-78-9
Molecular Formula:C₁₆H₂₄ClN₃O₂Si
Molecular Weight:353.924
Hs Code.:

Synonyms:5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine

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Chemical Property of 5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine

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Technology Process of 5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine

There total 3 articles about 5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1403963-77-8
5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole

: 1403963-78-9
5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 75 ℃; for 1.5h;
DOI:10.1021/jm3012239

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1403963-78-9
5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.17 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: catacxium A; potassium carbonate; Trimethylacetic acid / N,N-dimethyl-formamide / 6 h / 20 - 120 °C / Inert atmosphere

3.1: iron; ammonium chloride / water; ethanol / 1.5 h / 75 °C

With iron; sodium hydride; potassium carbonate; ammonium chloride; catacxium A; Trimethylacetic acid; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm3012239

Reference yield:

: 1260160-79-9
4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole

: 1403963-78-9
5-(5-chloro-2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: catacxium A; potassium carbonate; Trimethylacetic acid / N,N-dimethyl-formamide / 6 h / 20 - 120 °C / Inert atmosphere

2: iron; ammonium chloride / water; ethanol / 1.5 h / 75 °C

With iron; potassium carbonate; ammonium chloride; catacxium A; Trimethylacetic acid; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3012239