5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole

Base Information

Chemical Name:5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole
CAS No.:1403963-77-8
Molecular Formula:C₁₆H₂₂ClN₃O₄Si
Molecular Weight:383.907
Hs Code.:

Synonyms:5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole

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Technology Process of 5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole

There total 2 articles about 5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1260160-79-9
4-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole

: 60633-25-2
2-bromo-4-chloroanisole

: 1403963-77-8
5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole

Guidance literature:: With potassium carbonate; catacxium A; Trimethylacetic acid; In N,N-dimethyl-formamide; at 20 - 120 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jm3012239

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1403963-77-8
5-(5-chloro-2-methoxyphenyl)-4-nitro-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.17 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: catacxium A; potassium carbonate; Trimethylacetic acid / N,N-dimethyl-formamide / 6 h / 20 - 120 °C / Inert atmosphere

With sodium hydride; potassium carbonate; catacxium A; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm3012239