Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

Base Information

Chemical Name:Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate
CAS No.:253863-34-2
Molecular Formula:C₄₀H₄₆N₆O₁₂
Molecular Weight:802.838
Hs Code.:

Synonyms:Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

Suppliers and Price of Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

There total 13 articles about Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 253863-26-2
Aloc-D-Ala-Phe-Lys(Aloc)-PAB-OH

: 253863-34-2
Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

Guidance literature:: With pyridine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300714p

Reference yield:

: 253863-25-1
Aloc-D-Ala-Phe-Lys(Aloc)-OH

: 253863-34-2
Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran / 3 h / -40 - -30 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h

3: 67 percent / pyridine / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

With 4-methyl-morpholine; pyridine; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Substitution;
DOI:10.1021/jm9910472

Reference yield:

: 101214-43-1
Fmoc-Phe-ONSu

: 253863-34-2
Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / Et₃N / CH₂Cl₂ / 5 h / 20 °C

2: 2N aq. NaOH / dioxane; methanol / 1 h / 20 °C

3: Et₃N / CH₂Cl₂ / 16 h

4: HCl / ethyl acetate / 5 h

5: 86 percent / Et₃N / H₂O; acetonitrile / pH 3 - 9.5

6: N-methylmorpholine / tetrahydrofuran / 3 h / -40 - -30 °C

7: N-methylmorpholine / tetrahydrofuran / 2 h

8: 67 percent / pyridine / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile; 1: Substitution / 2: Hydrolysis / 3: Substitution / 4: Hydrolysis / 5: Substitution / 6: Substitution / 7: Substitution / 8: Substitution;
DOI:10.1021/jm9910472