Technology Process of Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate
There total 13 articles about Aloc-D-Ala-Phe-Lys(Aloc)-p-aminobenzyl oxycarbonyl p-nitrophenyl carbonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300714p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-methylmorpholine / tetrahydrofuran / 3 h / -40 - -30 °C
2: N-methylmorpholine / tetrahydrofuran / 2 h
3: 67 percent / pyridine / tetrahydrofuran; CH2Cl2 / 48 h / 20 °C
With
4-methyl-morpholine; pyridine;
In
tetrahydrofuran; dichloromethane;
1: Substitution / 2: Substitution / 3: Substitution;
DOI:10.1021/jm9910472
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 89 percent / Et3N / CH2Cl2 / 5 h / 20 °C
2: 2N aq. NaOH / dioxane; methanol / 1 h / 20 °C
3: Et3N / CH2Cl2 / 16 h
4: HCl / ethyl acetate / 5 h
5: 86 percent / Et3N / H2O; acetonitrile / pH 3 - 9.5
6: N-methylmorpholine / tetrahydrofuran / 3 h / -40 - -30 °C
7: N-methylmorpholine / tetrahydrofuran / 2 h
8: 67 percent / pyridine / tetrahydrofuran; CH2Cl2 / 48 h / 20 °C
With
4-methyl-morpholine; pyridine; hydrogenchloride; sodium hydroxide; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
1: Substitution / 2: Hydrolysis / 3: Substitution / 4: Hydrolysis / 5: Substitution / 6: Substitution / 7: Substitution / 8: Substitution;
DOI:10.1021/jm9910472
