(E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

Base Information

Chemical Name:(E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole
CAS No.:675123-19-0
Molecular Formula:C₁₉H₂₈N₂OSi
Molecular Weight:328.53
Hs Code.:

Synonyms:(E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

Suppliers and Price of (E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

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Technology Process of (E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

There total 5 articles about (E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 675123-18-9
1-(1-benzyl-1H-imidazol-4-yl)propen-3-ol

: 675123-19-0
(E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/ol036403w DOI:10.1021/jo0626008

Reference yield:

: 70346-51-9
(E)-methyl 3-(1H-imidazol-4-yl)acrylate

: 675123-19-0
(E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / NaH / dimethylformamide / 0 - 40 °C

2: 80 percent / DIBAL-H / CH₂Cl₂; hexane / -78 - 20 °C

3: 93 percent / imidazole / tetrahydrofuran / 3 h / 20 °C

With 1H-imidazole; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0626008

Reference yield:

: 675123-17-8
(2E)-3-(1-benzyl-1H-imidazol-4-yl)propenoic acid methyl ester

: 675123-19-0
(E)-1-benzyl-4-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / DIBAL-H / CH₂Cl₂; hexane / -78 - 20 °C

2: 93 percent / imidazole / tetrahydrofuran / 3 h / 20 °C

With 1H-imidazole; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo0626008