(4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine

Base Information

• Chemical Name: (4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine
• CAS No.: 714966-17-3
• Molecular Formula: C₂₂H₃₀ClN₂P
• Molecular Weight: 388.92
• Mol file: 714966-17-3.mol

Synonyms:(4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine

Chemical Property of (4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine

There total 1 articles about (4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R,R)-N,N'-di-tert-butyl-1,2-diphenyl-1,2-ethanediamine → (4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine (714966-17-3)

Guidance literature:

With triethylamine; phosphorus trichloride; In toluene; at 20 ℃; for 2h;

DOI:10.1002/chem.200305722

Reference yield:

diazomethyl-trimethyl-silane (18107-18-1) + (4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine (714966-17-3) → (4R,5R)-1,3-Di-tert-butyl-2-(diazo-trimethylsilanyl-methyl)-4,5-diphenyl-[1,3,2]diazaphospholidine (714966-15-1)

Guidance literature:

diazomethyl-trimethyl-silane; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

(4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/chem.200305722

Reference yield:

(4R,5R)-1,3-Di-tert-butyl-2-chloro-4,5-diphenyl-[1,3,2]diazaphospholidine (714966-17-3) → C26H39N2PSi (714966-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 1 h / 20 °C

2.1: toluene / 18 h / -40 °C / Irradiation

With n-butyllithium; In tetrahydrofuran; toluene;

DOI:10.1002/chem.200305722

Downstream raw materials:

(4R,5R)-1,3-Di-tert-butyl-2-(diazo-trimethylsilanyl-methyl)-4,5-diphenyl-[1,3,2]diazaphospholidine

C₂₆H₃₉N₂PSi