(R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid

Base Information

Chemical Name:(R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid
CAS No.:336101-58-7
Molecular Formula:C₂₄H₂₈O₇
Molecular Weight:428.482
Hs Code.:

Synonyms:(R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid

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Chemical Property of (R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid

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Technology Process of (R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid

There total 2 articles about (R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 630-19-3
pivalaldehyde

: 336101-54-3
(2R,3S)-2-(4-Benzyloxy-3-methoxy-benzyl)-3-hydroxy-succinic acid

: 336101-58-7
(R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid

: (R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2R,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid

Guidance literature:: With toluene-4-sulfonic acid; In benzene; Heating;
DOI:10.1021/jo001547z

Reference yield:

: 336101-52-1
(2R,3S)-2-[4-(benzyloxy)-3-methoxybenzyl]-3-hydroxybutanedioic acid diisopropyl ester

: 336101-58-7
(R)-3-(4-Benzyloxy-3-methoxy-phenyl)-2-((2S,4S)-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / KOH / ethanol / 72 h / 20 °C

2: 70 percent / p-TsOH / benzene / Heating

With potassium hydroxide; toluene-4-sulfonic acid; In ethanol; benzene;
DOI:10.1021/jo001547z