Technology Process of 8-(3-(Cyclohexylamino)propoxy)-9-methoxy-12-methyl-5,6-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]acridin-12-ium chloride
There total 10 articles about 8-(3-(Cyclohexylamino)propoxy)-9-methoxy-12-methyl-5,6-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]acridin-12-ium chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
8-(3-bromopropoxy)-9-methoxy-12-methyl-5,6-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]acridin-12-ium trifluoromethanesulfonate; cyclohexylamine;
With
potassium carbonate; potassium iodide;
In
dichloromethane;
at 20 ℃;
for 48h;
DOI:10.1016/j.ejmech.2012.03.034
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium fluoride / N,N-dimethyl-formamide / 6 h / 140 °C
2.1: trichlorophosphate / 8 h / Reflux
2.2: Saturated solution
3.1: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide / 3 h / 60 °C
4.1: sodium hydroxide / 1,4-dioxane / 2 h / 100 °C
4.2: pH 6 - 7 / Acidic conditions
5.1: potassium carbonate / acetonitrile / 3 h / 60 °C
6.1: toluene / 20 °C
7.1: potassium carbonate; potassium iodide / dichloromethane / 48 h / 20 °C
7.2: ion-exchange resin
With
potassium fluoride; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium iodide; sodium hydroxide; trichlorophosphate;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2012.03.034
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium permanganate / water; acetone / 2 h / 20 °C
2.1: iron; acetic acid / ethanol; water / 4 h / 20 °C
3.1: trichlorophosphate / 8 h / Reflux
3.2: Saturated solution
4.1: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide / 3 h / 60 °C
5.1: sodium hydroxide / 1,4-dioxane / 2 h / 100 °C
5.2: pH 6 - 7 / Acidic conditions
6.1: potassium carbonate / acetonitrile / 3 h / 60 °C
7.1: toluene / 20 °C
8.1: potassium carbonate; potassium iodide / dichloromethane / 48 h / 20 °C
8.2: ion-exchange resin
With
potassium permanganate; palladium 10% on activated carbon; hydrogen; iron; potassium carbonate; acetic acid; potassium iodide; sodium hydroxide; trichlorophosphate;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2012.03.034
![8-(3-bromopropoxy)-9-methoxy-12-methyl-5,6-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]acridin-12-ium trifluoromethanesulfonate](/Databaselist/images/loading.webp)
