methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate

Base Information

• Chemical Name: methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate
• CAS No.: 1026200-42-9
• Molecular Formula: C₁₈H₃₀N₂O₄
• Molecular Weight: 338.447
• Mol file: 1026200-42-9.mol

Synonyms:methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate

Chemical Property of methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate

There total 4 articles about methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(allyloxy)piperidine (946758-97-0) + methyl (2S)-cyclohexyl(isocyanato)acetate (1026200-41-8) → methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate (1026200-42-9)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 24h;

Reference yield:

N-tert-butoxycarbonyl-3-piperidinol (85275-45-2) → methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate (1026200-42-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 h

2.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C / Cooling with ice; Inert atmosphere

3.1: tetrahydrofuran / 24 h / 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate;

Reference yield:

methyl (2S)-amino(cyclohexyl)ethanoate hydrochloride (14328-63-3,14328-64-4) → methyl (2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetate (1026200-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 1 h / Cooling with ice

2: tetrahydrofuran / 24 h / 20 °C

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

3-(allyloxy)piperidine

methyl (2S)-cyclohexyl(isocyanato)acetate

N-tert-butoxycarbonyl-3-piperidinol

tert-butyl 3-(allyloxy)piperidine-1-carboxylate

Downstream raw materials:

(2S)-({[3-(allyloxy)piperidin-1-yl]carbonyl}amino)(cyclohexyl)acetic acid