cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide

Base Information

Chemical Name:cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide
CAS No.:1579977-41-5
Molecular Formula:C₂₄H₂₈F₂N₄O₂
Molecular Weight:442.509
Hs Code.:

Synonyms:cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide

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Chemical Property of cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide

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Technology Process of cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide

There total 2 articles about cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 438585-72-9
5-(3,5-difluorophenyl)pyridin-2-ylamine

: C₁₃H₂₁ClN₂O₂

: 1579977-41-5
cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; for 18h; Reflux;
DOI:10.1016/j.bmcl.2014.02.023

Reference yield:

: 1579977-53-9
cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid

: 1579977-41-5
cis-4-(3-isopropyl-2-oxoimidazolidin-1-yl)cyclohexanecarboxylic acid [5-(3,5-difluorophenyl)pyridin-2-yl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 18 h / Reflux

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2014.02.023