Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate

Base Information

Chemical Name:Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate
CAS No.:1026929-37-2
Molecular Formula:C₂₄H₂₈NO₇PS
Molecular Weight:505.529
Hs Code.:

Synonyms:Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate

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Chemical Property of Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate

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Technology Process of Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate

There total 8 articles about Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 958238-20-5
Ethyl 3'-<1-(phenylsulfonyl)-3-(bromomethyl)indol-2-yl>acrylate

: 122-52-1
triethyl phosphite

: 1026929-37-2
Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate

Guidance literature:: Heating;
DOI:10.1021/jo00112a011

Reference yield:

: 91-55-4
2,3-dimethylindole

: 1026929-37-2
Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / NaH / tetrahydrofuran

2: 92 percent / NBS, benzoyl peroxide / CCl₄ / Heating

3: H₂O, NaHCO₃ / acetonitrile / 2 h / Heating

4: MnO₂ / 1,2-dichloro-ethane / 12 h / Heating

5: 85 percent / tetrahydrofuran / Heating

6: 96 percent / NBS, benzoyl peroxide / CCl₄ / Heating

7: 91 percent / Heating

With manganese(IV) oxide; N-Bromosuccinimide; Perbenzoic acid; water; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; tetrachloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo00112a011

Reference yield:

: 116325-48-5
N-benzenesulfonyl-2,3-dimethyl-1H-indole

: 1026929-37-2
Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / NBS, benzoyl peroxide / CCl₄ / Heating

2: H₂O, NaHCO₃ / acetonitrile / 2 h / Heating

3: MnO₂ / 1,2-dichloro-ethane / 12 h / Heating

4: 85 percent / tetrahydrofuran / Heating

5: 96 percent / NBS, benzoyl peroxide / CCl₄ / Heating

6: 91 percent / Heating

With manganese(IV) oxide; N-Bromosuccinimide; Perbenzoic acid; water; sodium hydrogencarbonate; In tetrahydrofuran; tetrachloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo00112a011