(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid

Base Information

• Chemical Name: (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid
• CAS No.: 1622307-41-8
• Molecular Formula: C₂₂H₁₅NO₅S
• Molecular Weight: 405.431

Synonyms:(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid

Chemical Property of (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid

There total 8 articles about (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

(E)-methyl 3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylate → (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid (1622307-41-8)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

5-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)picolinaldehyde (1622309-43-6) → (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid (1622307-41-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 18 h / 0 - 20 °C

2: boron tribromide / dichloromethane; n-heptane / 0.5 h / 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With water; boron tribromide; lithium hydroxide; In tetrahydrofuran; n-heptane; dichloromethane;

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid (1622307-41-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

2.2: 1.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 18 h / 80 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

5.1: manganese(IV) oxide / dichloromethane / 48 h / 20 °C

6.1: dichloromethane / 18 h / 0 - 20 °C

7.1: boron tribromide / dichloromethane; n-heptane / 0.5 h / 20 °C

8.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With manganese(IV) oxide; N-Bromosuccinimide; lithium aluminium tetrahydride; water; boron tribromide; sodium hydride; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

methyl 5-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)picolinate

(5-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)methanol

5-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)picolinaldehyde

(E)-methyl 3-(5-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylate

Downstream raw materials:

(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

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