(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

Base Information

Chemical Name:(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide
CAS No.:1622307-87-2
Molecular Formula:C₂₃H₁₈N₂O₄S
Molecular Weight:418.473
Hs Code.:

Synonyms:(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

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Chemical Property of (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

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Technology Process of (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

There total 9 articles about (E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1622307-41-8
(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylic acid

: 593-51-1
methylamine hydrochloride

: 1622307-87-2
(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 176672-06-3
3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

: 1622307-87-2
(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 18 h / 80 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

4.1: manganese(IV) oxide / dichloromethane / 48 h / 20 °C

5.1: dichloromethane / 18 h / 0 - 20 °C

6.1: boron tribromide / dichloromethane; n-heptane / 0.5 h / 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

8.1: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 48 h / 20 °C

With 4-methyl-morpholine; manganese(IV) oxide; lithium aluminium tetrahydride; water; boron tribromide; sodium hydride; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil; 8.1: |Heck Reaction;

Reference yield:

: 1622309-41-4
methyl 5-((6-methoxy-2-(4-methoxyphenyl)-1-oxidobenzo[b]thiophen-3-yl)oxy)picolinate

: 1622307-87-2
(E)-3-(5-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)-N-methylacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: manganese(IV) oxide / dichloromethane / 48 h / 20 °C

3: dichloromethane / 18 h / 0 - 20 °C

4: boron tribromide / dichloromethane; n-heptane / 0.5 h / 20 °C

5: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

6: HATU; 4-methyl-morpholine / N,N-dimethyl-formamide / 48 h / 20 °C

With 4-methyl-morpholine; manganese(IV) oxide; lithium aluminium tetrahydride; water; boron tribromide; HATU; lithium hydroxide; In tetrahydrofuran; n-heptane; dichloromethane; N,N-dimethyl-formamide; 6: |Heck Reaction;