C₂₇H₂₆N₂O₄

Base Information

• Chemical Name: C₂₇H₂₆N₂O₄
• CAS No.: 1572571-97-1
• Molecular Formula: C₂₇H₂₆N₂O₄
• Molecular Weight: 442.514
• Mol file: 1572571-97-1.mol

Synonyms:C₂₇H₂₆N₂O₄

Chemical Property of C₂₇H₂₆N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₆N₂O₄

There total 6 articles about C₂₇H₂₆N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C24H23NO4 (1572571-96-0) + acrylonitrile (107-13-1,25014-41-9) → C27H26N2O4 (1572571-97-1)

Guidance literature:

C₂₄H₂₃NO₄; With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at 0 ℃; for 0.166667h;

acrylonitrile; In tetrahydrofuran; tert-butyl alcohol; at 0 ℃; for 0.05h;

DOI:10.1021/jo402741g

Reference yield:

2-methoxy-phenylamine (90-04-0) → C27H26N2O4 (1572571-97-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / toluene

2.1: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 3 h / 140 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 °C / Inert atmosphere

5.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.17 h / 0 °C

5.2: 0.05 h / 0 °C

With potassium tert-butylate; copper diacetate; palladium diacetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil; tert-butyl alcohol;

DOI:10.1021/jo402741g

Reference yield:

3-(2-Methoxy-phenylamino)-cyclohex-2-enone (73825-32-8) → C27H26N2O4 (1572571-97-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium diacetate; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 3 h / 140 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.17 h / 0 °C

4.2: 0.05 h / 0 °C

With potassium tert-butylate; copper diacetate; palladium diacetate; sodium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

DOI:10.1021/jo402741g

upstream raw materials:

3-(2-Methoxy-phenylamino)-cyclohex-2-enone

2-methoxy-phenylamine

1,3-cylohexanedione

C₂₀H₁₉NO₂

Downstream raw materials:

C₂₆H₂₈N₂O₂

C₂₆H₃₀N₂O

C₂₆H₂₆N₂O₂

C₂₆H₂₈N₂O₃