1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

Base Information

Chemical Name:1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol
CAS No.:154544-31-7
Molecular Formula:C₂₂H₂₉IO₈
Molecular Weight:548.372
Hs Code.:

Synonyms:1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

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Technology Process of 1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

There total 3 articles about 1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 154544-30-6
1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione

: 154544-31-7
1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; water; for 2.5h; Ambient temperature;
DOI:10.1021/jm980046r

Reference yield:

: 5438-36-8
5-iodovaniline

: 154544-31-7
1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 50 deg C, 20 h

2: 51 percent / 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, triethylamine / 16 h / 60 °C

3: 99 percent / NaBH₄ / tetrahydrofuran; methanol; H₂O / 2.5 h / Ambient temperature

With sodium tetrahydroborate; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm980046r

Reference yield:

: 154544-29-3
4-(2-hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde

: 154544-31-7
1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, triethylamine / 16 h / 60 °C

2: 99 percent / NaBH₄ / tetrahydrofuran; methanol; H₂O / 2.5 h / Ambient temperature

With sodium tetrahydroborate; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm980046r