4-(2-Hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde

Base Information

• Chemical Name: 4-(2-Hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde
• CAS No.: 154544-29-3
• Molecular Formula: C10H11IO4
• Molecular Weight: 322.099
• DSSTox Substance ID: DTXSID40364895
• Wikidata: Q82149098
• Mol file: 154544-29-3.mol

Synonyms:4-(2-hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde;154544-29-3;Benzaldehyde, 4-(2-hydroxyethoxy)-3-iodo-5-methoxy-;SCHEMBL7122419;DTXSID40364895;STK400659;AKOS000303977;3-Methoxy-4-hydoxyethoxy-5-iodobenzaldehyde;AK-968/40709987

Chemical Property of 4-(2-Hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 321.97021
• Heavy Atom Count: 15
• Complexity: 200

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC(=C1)C=O)I)OCCO

Technology Process of 4-(2-Hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde

There total 1 articles about 4-(2-Hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Iodoethanol (624-76-0) + 5-iodovaniline (5438-36-8) → 4-(2-hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde (154544-29-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 30 min, 2.) DMF, 50 deg C, 20 h;

DOI:10.1021/jm980046r

Reference yield: 90.0%

methanesulfonyl chloride (124-63-0) + 4-(2-hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde (154544-29-3) → 2-(4-formyl-2-iodo-6-methoxyphenoxy)ethyl methane-sulfonate

Guidance literature:

With triethylamine; at 20 ℃; for 2h;

DOI:10.14233/ajchem.2016.19776

Reference yield: 51.0%

1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (106331-50-4) + 4-(2-hydroxyethoxy)-3-iodo-5-methoxybenzaldehyde (154544-29-3) → 1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione (154544-30-6)

Guidance literature:

With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; triethylamine; at 60 ℃; for 16h;

DOI:10.1021/jm980046r

upstream raw materials:

Iodoethanol

5-iodovaniline

Downstream raw materials:

1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione

1-(3-methoxy-4-hydroxyethoxy-5-iodophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol

(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran