6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide

Base Information

Chemical Name:6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide
CAS No.:1246494-52-9
Molecular Formula:C₂₃H₂₆FN₇O₃
Molecular Weight:467.503
Hs Code.:

Synonyms:6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide

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Chemical Property of 6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide

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Technology Process of 6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide

There total 5 articles about 6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

: 1363568-77-7
di(tert-butyl) [5-({[(4-{6-(ethylamino)-5-[(2-hydroxyethyl)carbamoyl]pyridin-2-yl}-2-fluorophenyl)carbamoyl]amino}methyl)pyridin-2-yl]imidodicarbonate

: 1246494-52-9
6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide

Guidance literature:: di(tert-butyl) [5-({[(4-{6-(ethylamino)-5-[(2-hydroxyethyl)carbamoyl]pyridin-2-yl}-2-fluorophenyl)carbamoyl]amino}methyl)pyridin-2-yl]imidodicarbonate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h; Cooling;

With sodium carbonate;

Reference yield:

: 819058-34-9
2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1246494-52-9
6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / tetrahydrofuran / 18 h / 20 °C

1.2: 5 h / 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 6 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C / Cooling

With dmap; sodium hydrogencarbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1246494-52-9
6-{4-[3-(6-aminopyridin-3-ylmethyl)ureido]-3-fluorophenyl}-2-ethylamino-N-(2-hydroxyethyl)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: water / 120 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 70 h / 20 °C

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 6 h / Inert atmosphere; Reflux

4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C / Cooling

With sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water;