6-Chloro-2-ethylaMinonicotinic Acid

Base Information

• Chemical Name: 6-Chloro-2-ethylaMinonicotinic Acid
• CAS No.: 1092523-21-1
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.625
• Mol file: 1092523-21-1.mol

Synonyms:6-chloro-2-(ethylamino)pyridine-3-carboxylic acid

Chemical Property of 6-Chloro-2-ethylaMinonicotinic Acid

Chemical Property:

• Boiling Point: 384.6±42.0 °C(Predicted)
• PKA: 3.28±0.36(Predicted)
• Density: 1.401±0.06 g/cm3(Predicted)
• Solubility.: Acetone, Ethyl Acetate

Purity/Quality:

98% ^*data from raw suppliers

6-?Chloro-?2-?ethylaminonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-?Chloro-?2-?ethylaminonicotinic Acid is an intermediate in the synthesis of SAR131675 (S139510), is a potent and selective VEGFR-3 inhibitor.

Technology Process of 6-Chloro-2-ethylaMinonicotinic Acid

There total 1 articles about 6-Chloro-2-ethylaMinonicotinic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

2,6-dichloropyridine-3-carboxylic acid (38496-18-3) + ethylamine (75-04-7,85404-22-4) → 6-chloro-2-(ethylamino)pyridine-3-carboxylic acid (1092523-21-1)

Guidance literature:

In water; at 20 ℃; for 120h;

Reference yield: 97.4%

6-chloro-2-(ethylamino)pyridine-3-carboxylic acid (1092523-21-1) + 1-(pyridinyl-3-yl)methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]urea (874298-23-4) → 2-Ethylamino-6-[4-(3-(pyridin-3-ylmethyl)ureido)phenyl]nicotinic acid (1138322-05-0)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; at 20 - 90 ℃; Inert atmosphere;

Reference yield:

6-chloro-2-(ethylamino)pyridine-3-carboxylic acid (1092523-21-1) + di(tert-butyl) {5-[({[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamoyl}amino)methyl]pyridin-2-yl}imidodicarbonate (1246494-90-5) → C26H29FN6O5 + 6-(4-{[({6-[(bis-tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)carbamoyl]amino}-3-fluorophenyl)-2-(ethylamino)nicotinic acid (1246494-92-7)

Guidance literature:

With sodium hydrogencarbonate; In 1,2-dimethoxyethane; ethanol; for 18h; Inert atmosphere; Reflux;

upstream raw materials:

2,6-dichloropyridine-3-carboxylic acid

ethylamine

Downstream raw materials:

6-chloro-2-(ethylamino)pyridine-3-carbonyl fluoride

2-Ethylamino-6-[4-(3-(pyridin-3-ylmethyl)ureido)phenyl]nicotinic acid

2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

2-amino-1-ethyl-7-{4-[2-({[(2S)-1-ethyl-4,4-difluoropyrrolidin-2-yl]methyl}-amino)-2-oxoethyl]phenyl}-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Refernces

• 1、 -. "PYRIDINO-PYRIDINONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF". Page/Page column 14. . Retrieved 2013/02/28.
• 2、 -. "ANTICANCER COMPOUNDS, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF". Page/Page column 8. . Retrieved 2012/03/12.