2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

Base Information

Chemical Name:2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid
CAS No.:81321-28-0
Molecular Formula:C₁₈H₁₄ClFN₂O₂
Molecular Weight:344.773
Hs Code.:

Synonyms:2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

Suppliers and Price of 2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

There total 8 articles about 2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 2-<4-(4-Chlorphenyl)-1-(4-fluorphenyl)-3-pyrazolyl>-propionitril

: 81321-28-0
2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

Guidance literature:: With sodium hydroxide; In water; dimethyl sulfoxide; at 120 ℃; for 3h;

Reference yield:

: 81321-57-5
<4-(4-Chlorphenyl)-1-(4-fluorphenyl)-3-pyrazolyl>-methanol

: 81321-28-0
2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / 63percent HBr / H₂O / 8 h / 80 - 90 °C

2: 91 percent / dibenzo-18-crown-6 / acetonitrile / 1.) 50 deg C, 2.) 3 h, 80 deg C

3: 76 percent Chromat_. / tetrabutylammonium hydrogen sulfate, 1N NaOH / CH₂Cl₂; H₂O / 16 h / Ambient temperature

4: 48 percent / NaOH / H₂O; dimethylsulfoxide / 3 h / 120 °C

With sodium hydroxide; dibenzo-18-crown-6; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 81321-66-6
3-Brommethyl-4-(4-chlorphenyl)-1-(4-fluorphenyl)-pyrazol

: 81321-28-0
2-[4-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / dibenzo-18-crown-6 / acetonitrile / 1.) 50 deg C, 2.) 3 h, 80 deg C

2: 76 percent Chromat_. / tetrabutylammonium hydrogen sulfate, 1N NaOH / CH₂Cl₂; H₂O / 16 h / Ambient temperature

3: 48 percent / NaOH / H₂O; dimethylsulfoxide / 3 h / 120 °C

With sodium hydroxide; dibenzo-18-crown-6; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; dimethyl sulfoxide; acetonitrile;