9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one

Base Information

Chemical Name:9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one
CAS No.:851107-69-2
Molecular Formula:C₂₉H₂₇ClO₄
Molecular Weight:474.984
Hs Code.:

Synonyms:9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one

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Chemical Property of 9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one

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Technology Process of 9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one

There total 6 articles about 9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851107-68-1
4-bromo-9a-(4-chlorobenzyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

: tributyl-(4-methoxymethoxyphenyl)-stannane

: 851107-69-2
9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 24h;
DOI:10.1021/jm060516e

Reference yield:

: 2-(4-chlorobenzylidene)-5-methoxy-1-indanone

: 851107-69-2
9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / selenium; sodium borohydride / tetrahydrofuran / 2 h / 50 °C

2.1: DBU / tetrahydrofuran / 4 h / 55 °C

2.2: pyrrolidine; HOAc / tetrahydrofuran / 9 h / 55 °C

3.1: NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

4.1: tetrakis(triphenylphosphine)-palladium⁽⁰⁾ / toluene / 24 h / 100 °C

With selenium; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; toluene; 4.1: Stille coupling;
DOI:10.1021/jm060516e

Reference yield:

: 851107-66-9
2-(4-chlorobenzyl)-5-methoxy-1-indanone

: 851107-69-2
9a-(4-chloro-benzyl)-7-methoxy-4-(4-methoxymethoxy-phenyl)-1,2,9,9a-tetrahydro-fluoren-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: DBU / tetrahydrofuran / 4 h / 55 °C

1.2: pyrrolidine; HOAc / tetrahydrofuran / 9 h / 55 °C

2.1: NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

3.1: tetrakis(triphenylphosphine)-palladium⁽⁰⁾ / toluene / 24 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; toluene; 3.1: Stille coupling;
DOI:10.1021/jm060516e